Ferulic acid as anticarcinogenic agent against 1,2-dimethylhydrazine induced colon cancer in rats
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چکیده
منابع مشابه
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
alpha-Difluoromethylornithine (DFMO) treatment has been shown to modify carcinogenesis in many experimental tumor models, including breast, urinary bladder, and colon. This study was designed to determine whether DFMO treatment can inhibit tumor growth on chemical-induced colon cancer in rats. Effectiveness of DFMO in combination with mitomycin C (MMC) was also evaluated. Forty-two Sprague-Dawl...
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Transplantation of placenta-derived multipotent cells (PDMCs) is a promising treatment method for many diseases. However, the impact of PDMCs on colon cancer has not yet been studied. PDMCs were obtained from rat placentas by culturing tissue explants. Colon cancer was experimentally induced in male albino Wistar rats by administering 20 mg/kg dimethylhydrazine (DMH) once a week for 20 consecut...
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Background: Colon cancer is considered as the third most common cancer affecting both developed and developing countries. In the current study, n-butylidenephthalide (BP) a compound extracted from traditional Chinese herb Radix Angelica sinensi was assessed against 1,2-dimethylhydrazine (DMH)-induced colon cancer. Materials and Methods: To promote colon cancer, DMH (20 mg kgG1, s.c.) was admini...
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The biochemical and clinical effects of selenium (Na2SeO3) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Sprague-Dawley rats are presented. A 4-ppm selenium supplement to the drinking water was provided before, during, and after 20 weekly injections of 20 mg DMH per kg body weight. Immediately after the 20th DMH injection, part of the rats were sacrificed. The incidences o...
متن کاملHepatoprotective effect of methyl ferulic acid against carbon tetrachloride-induced acute liver injury in rats
The present study aimed to investigate the hepatoprotective effects of methyl ferulic acid (MFA) against oxidative stress and apoptosis in acute liver injury induced by carbon tetrachloride (CCl4) in rats, as well as the underlying mechanisms. Sprague Dawley rats were treated with CCl4 after oral administration of MFA (25, 50, and 100 mg/kg) or dimethyl diphenyl bicarboxylate (200 mg/kg) for 7 ...
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ژورنال
عنوان ژورنال: Journal of King Saud University - Science
سال: 2021
ISSN: 1018-3647
DOI: 10.1016/j.jksus.2021.101354